cloud computing technology

Thursday, December 13, 2012

Tumble over the 'patent cliff' fosters innovation in developing new medicines

Public release date: 12-Dec-2012
[ | E-mail |

Share ]

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

All eyes may be on Washington this month as the White House and Congress confront the fiscal cliff, but the industry that produces life-saving medications has recently gone over its own counterpart the patent cliff. That's the topic of the cover story in the current edition of Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, the world's largest scientific society.

Rick Mullin, C&EN senior editor, explains that in the last 18 months, major pharmaceutical companies like Pfizer, Eli Lilly & Co. and AstraZeneca lost patents on some of their best-selling drugs. These included the anti-cholesterol medicine Lipitor, blood-thinner Plavix and schizophrenia drugs Zyprexa and Seroquel IR. In the U.S., patents on drugs last for 20 years, after which other companies are free to market generic versions. The loss of revenue combined with the global recession has sent manufacturers of such blockbuster medicines looking for better ways to develop new drugs.

Mullin describes how innovations are raising hopes for new drugs and profits as 2013 approaches. A cornerstone of the new approach is a focus on pairing low costs with high quality. The industry is also taking a fresh look at potential new drugs for Parkinson's, Alzheimer's and other unmet medical needs. In addition, drug companies are pursuing new research partnerships with universities, expanding their international markets, shrinking their staffs and buying up smaller biotechnology firms.

###

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 164,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.

Follow us: Twitter | Facebook

[ | E-mail | Share ]
?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Tumble over the 'patent cliff' fosters innovation in developing new medicines Public release date: 12-Dec-2012
[ | E-mail | Share ]
Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

All eyes may be on Washington this month as the White House and Congress confront the fiscal cliff, but the industry that produces life-saving medications has recently gone over its own counterpart the patent cliff. That's the topic of the cover story in the current edition of Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, the world's largest scientific society.

Rick Mullin, C&EN senior editor, explains that in the last 18 months, major pharmaceutical companies like Pfizer, Eli Lilly & Co. and AstraZeneca lost patents on some of their best-selling drugs. These included the anti-cholesterol medicine Lipitor, blood-thinner Plavix and schizophrenia drugs Zyprexa and Seroquel IR. In the U.S., patents on drugs last for 20 years, after which other companies are free to market generic versions. The loss of revenue combined with the global recession has sent manufacturers of such blockbuster medicines looking for better ways to develop new drugs.

Mullin describes how innovations are raising hopes for new drugs and profits as 2013 approaches. A cornerstone of the new approach is a focus on pairing low costs with high quality. The industry is also taking a fresh look at potential new drugs for Parkinson's, Alzheimer's and other unmet medical needs. In addition, drug companies are pursuing new research partnerships with universities, expanding their international markets, shrinking their staffs and buying up smaller biotechnology firms.

###

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 164,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.

Follow us: Twitter | Facebook

[ | E-mail | Share ]
?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-12/acs-tot121212.php
white sox chuck colson ufc 145 results

Wednesday, December 12, 2012

'The Bourne Legacy' Exclusive Blu-ray Clip Reveals Filming Challenges

"The Bourne Legacy" faced some major challenges beyond just finding a leading actor suitable to fill the shoes emptied by Matt Damon. A good portion of the movie was shot in Alberta, Canada, and MTV News has an exclusive behind-the-scenes clip from the movie's Blu-ray release that details just how difficult it was for the [...]

Source: http://moviesblog.mtv.com/2012/12/11/bourne-legacy-exclusive-blu-ray-clip/

lucid 2012 ncaa tournament bracket matterhorn chris harrison girl scouts printable bracket game change

Sunday, December 9, 2012

W. Ice Hockey. Gophers Remain Undefeated, Break NCAA Record

Dec. 7, 2012?

?Scoring Summary
Second Period
MINN	10:22	Brandt (19)	Bozek, Kortum
MINN	12:03	Stecklein (3)	Kessel
MINN	14:18	Lorence (5)	Kessel, Bozek
Third Period
MINN	3:21	Bozek (9)	Lorence, Kessel
MINN	9:41	Kortum (8)	Ramsey, Bona
BSU	16:32	Huber (2)	Kostenko

?Team Statistics
?	MINN	BSU
?Shots on Goal	34	27
?Power Play	1-6	0-5
?Penalties	7-14	6-12

With a 5-1 win at Bemidji State on Friday night, the University of Minnesota women?s hockey team extended its road winning streak to 16 games, a new NCAA record. Megan Bozek and Amanda Kessel each contributed three points for the No. 1 Golden Gophers.

Both teams were scoreless through the first period and a half of action, but the Gophers grabbed the lead in the middle of the second. Minnesota had a 4-on-3 advantage when Bozek fired a shot that deflected off Becky Kortum. Hannah Brandt slapped the rebound into the back side of the goal to put the Gophers ahead 1-0 at the 10:22 mark. Bozek and Kortum were credited with assists.

Minnesota added a shorthanded goal at 12:03. Kessel had a breakaway down the right side of the net. Lee Stecklein got out of the penalty box and skated to the near post. Kessel passed the puck past a Bemidji State defender to Stecklein for a goal from just outside the crease.

The Gophers added a third goal in the period, with Kessel again playing a major role in the scoring opportunity. Bozek passed to Kessel, who skated toward the goal. She was tripped, but managed to pass the puck off of a Beaver player as she fell. Meghan Lorence backhanded it into the net for a 3-0 lead. Kessel and Bozek each had an assist.

Bozek blasted in a goal of her own from the blue line early in the third. Kessel and Lorence had the assists. Kortum made it 5-0 on a breakout right after a Gopher faceoff win later in the period. Rachel Ramsey and Stecklein were credited with assists.

The Beavers ended the shutout bid at 16:34 in the third with a Kristin Huber goal assisted by Natasha Kostenko. Minnesota goalie Noora R?ty stopped the other 27 Beaver shots on goal to pick up her 93rd career win.

With a win or a tie tomorrow, the Gophers would break the record for longest unbeaten streak in school history. They tied the record tonight by extending their streak to 26 games. The Gophers and Beavers will conclude this weekend?s series tomorrow at 4:07 p.m. at the Sanford Center.

Source: http://onlyfans.cstv.com/schools/minn/sports/w-hockey/recaps/120712aab.html

reason rally mad hatter azerbaijan ryan howard ps i love you ray charles cheney heart transplant

S.E.O ! Submitting To Search Sites. | Moonlight Websites|Website ...

What a Search Engine Optimisation Firm Can Do for You how does one sell to individuals that are unaware of the fact that you exist? This will be your most important quandary if you set up your business web site and do not consult a search engine optimisation firm for SEO information. You'll fade into incompetency, a failure even before you have even started. This rule of the Net is as definite as the undeniable fact of physics the earth is round. The Seriousness of Search Site Visibility The best proportion of focused net traffic will come from the search websites. Web executives may ferociously dialogue about the particular proportion of quality net traffic due to the search sites, but they may all agree with dispatch the search site is an important source of valuable internet traffic.

When folk type in your keywords into the search website your content will come up, and you'll get traffic to your internet site. Search engine optimisation by employing keywords and keywords guarantees you get highly targeted traffic to your internet site. You made your content identifiable to the search websites by employing keywords that have relevancy to your site. Learn Search Engine Optimisation : When you learn Search engine optimisation you may become one of the few successful Social promoters who make cash on line. Just go to the site below to examine it.

I've already attended webinars with Tissa, and actually have spoken with him. If you're also already in web-based promoting, you add this to your business as an extra revenue stream. You get free coaching, you can talk directly to the owner, who incidentally is particularly helpful, and will give you all of the tips that you will need to learn and build you business. I have analyzed so intently about this business to accept it 100 pc. With your basic know-how about building internet sites and internet based marketing, you can connect to local smaller enterprises in your neighborhood and give them something that they Despairingly need ? a web presence. To them, building an internet site or promoting online sounds rather like a complete headache and appears too difficult. The truth is, most smaller enterprises do not know the first thing about building web sites. These are folks from a different generation.

They may index those pages, which have maximum keywords and rank them higher in the search result. Clearly , the surfers, the majority of the times will push the first web link provided thru the result. Keywords like roles in Denver, work openings in Denver, for example. While utilizing the job search websites, work seekers must provide acceptable keywords to get the precise result.

Source: http://www.moonlightwebsites.com/archives/445/s-e-o-submitting-to-search-sites/?utm_source=rss&utm_medium=rss&utm_campaign=s-e-o-submitting-to-search-sites

Olympics 2012 Schedule Kenneth Branagh Lupe Ontiveros London 2012 China muhammad ali Opening ceremony London 2012 Google Fiber

Source: http://andrews84.typepad.com/blog/2012/12/seo-submitting-to-search-sites-moonlight-websiteswebsite.html

charlotte bobcats new york rangers nfl mock draft 2012 norfolk island michael brockers lisa marie presley florida panthers

Saturday, December 8, 2012

Send messages of thanks, holiday cheer to troops now through Dec. 7

(KFVS) - The American Red Cross will be collecting and distributing cards that send words of encouragement, gratitude and cheer to America's heroes for the holiday season.

The Red Cross is inviting the public to send messages of thanks and holiday cheer until Dec. 7 by mailing them to:

Holiday Mail for Heroes
P.O. Box 5456
Capitol Heights, MD 20791-5456

To ensure that cards are delivered on time for the holidays, the Red Cross says they must be postmarked no later than Dec. 7. Individuals are asked to refrain from sending "care packages," monetary donations or using glitter or any other kinds of inserts with the cards.

According to the Red Cross, the company Pitney Bowes Inc. receives cards at the special Holiday Mail post office box, and screens them for hazardous materials. The company screens, packages and ships the cards at no charge.

Red Cross volunteers across the United States and on military installations overseas then sort and deliver the cards throughout the holiday season. The Red Cross and Pitney Bowes have received and distributed more than 4.7 million cards for members of the U.S. Armed Forces, veterans and their families since the program began in 2006.

For more information, you can click here to visit the Red Cross online.

Source: http://perry-illinois.kfvs12.com/news/community-spirit/60104-send-messages-thanks-holiday-cheer-troops-now-through-dec-7

chocolate covered strawberries shrimp scampi kate upton si cover lobster recipes hearts roses flower delivery

Questions To Ask Your Web Hosting Service Supplier | My Six ...

On-line Yellow pages are already in use for years. Internet corporations understand how worthwhile the Telephone book are often if implemented the ideal way, even so the the vast majority of them are so centered on using the other resources that they fall short to generate usage of it. The biggest reason for employing world-wide-web phone book is your target market is browsing them and when you don?t allow them obtain you there, you lose a possibility for getting added potential customers.

One of the several chief explanations you have to be using the World-wide-web Phone book is it happens to be a basic tactic to obtain a nice rating for your key key words, because this is the perfectly respected authority internet site with the eyes belonging to the engines like google. It is an increased targeted traffic web page by having an excessive web site rank, and also a sensible ranking with Alexa. So at the time you have your web site related to these websites, it will not merely enable you get yourself a fine search engine placement, though the inbound links that you obtain for your personal page may have extended word worth. Secondly, it is advisable to make certain that you are selecting the correct category when you?re distributing your itemizing with the Phone book online. You prefer the appropriate individuals to come throughout your online business whenever they lookup the directory. The general response in your submission might possibly be affected by this so never feel it isn?t really critical. Enterprises get labeled within the Online Phone book by elements which include the type of merchandise bought, age on the industry, and annual sales volume.

Last but not the least; will not limit oneself even while publishing your enterprise, since the a great deal more On-line Yellow pages you end up picking to opt for, the upper level of exposure you certainly will acquire. Your focused buyers are spread around the internet so they will use various kinds of yellow pages to search on your type of business. When you?ve your listing ready, the true process of itemizing your organization will not likely take that prolonged. The only thing you need to target on is excellent quality and make sure that you?re having each one and every action quite possible for making your corporation presentable before your potential clients.

No matter what market you?re in, you can utilize the internet Phone book to aid you have the word out regarding your internet marketing business and provide potential clients for your web page. If you need to faucet right into a sizeable pool of people without charge, start out utilizing the On line Yellow pages now a days and acquire the most from your online business. That is just one uncomplicated advertising tactic that will provide help to enhance awareness of one?s online business and acquire you alot more site traffic and product sales.

Shanix Pineda serves as a soaring star during the blogging society who writes articles or blog posts on affiliate marketing online, promotion and Multi-level marketing. His enthusiasm for running a blog draws readers throughout the whole world. Checkout his posts on Multi level marketing achievement techniques and on Empower Network hints

What To Search For In A Web Hosting Package can present you with optimum data for An Explanation Of Internet Hosting.Please look at the article for additional data!

How To Decide On An Acceptable Web Hosting Service Supplier
Is Top Web Hosting Service Providers One Of The Best Web Hosting Supplier In The International Market
How To Decide On A Suitable Web Hosting Service Supplier
Questions To Ask Your Web Hosting Service Provider
Choosing The Most Effective Internet Hosting Service Supplier

Source: http://mysixstringsblog.com/questions-to-ask-your-web-hosting-service-supplier/?utm_source=rss&utm_medium=rss&utm_campaign=questions-to-ask-your-web-hosting-service-supplier

braxton miller braxton miller Whitney Heichel Tippi Hedren Big Tex Sweetest Day optimal

Vols hire Cincinnati's Jones as new football coach

FILE - In this Saturday, Dec. 1, 2012 file photo, Cincinnati head coach Butch Jones gestures during the second half of an NCAA college football game against Connecticut at Rentschler Field in East Hartford, Conn. Tennessee has hired Jones as its next football coach, the school announced Friday, Dec. 7, 2012. (AP Photo/Jessica Hill, File)

FILE - In this Oct. 20, 2012, file photo, Cincinnati Bearcats head coach Butch Jones yells during the second quarter of an NCAA college football game against the Toledo Rockets in Toledo, Ohio. The bowl-bound Bearcats wait to hear from coach Jones about whether he'll stay or head off to either Purdue or Colorado. (AP Photo/David Richard, File)

Cincinnati coach Butch Jones cheers on his team after a touchdown in the second half of the team's 27-10 win over South Florida in an NCAA college football game, Friday, Nov. 23, 2012, in Cincinnati. (AP Photo/Al Behrman)

FILE - In this Oct. 13, 2012, file photo, Cincinnati head coach Butch Jones, left, slaps hands with his players as they run off the field after scoring a touchdown in the second half of an NCAA college football game against Fordham in Cincinnati. The bowl-bound Bearcats wait to hear from coach Jones about whether he'll stay or head off to either Purdue or Colorado. (AP Photo/Al Behrman, File)

KNOXVILLE, Tenn. (AP) ? Butch Jones wasn't Tennessee's first choice as its next football coach. The Volunteers believe the former Cincinnati coach will prove he's the right choice.

Tennessee announced Friday morning that Jones had agreed to become its fourth coach in six seasons, ending a tumultuous couple of days for both parties. Tennessee has scheduled a Friday afternoon news conference to announce the hiring, which was first reported by VolQuest.com.

"It is truly an honor and a privilege to be the head football coach at the University of Tennessee," Jones said in a statement. "I understand the values, traditions and level of expectations that come with this position, and I look forward to being a part of the Vol Nation."

Jones, 44, has a 50-27 record in six seasons as a head coach. He went 27-13 in three seasons at Central Michigan and was 23-14 at Cincinnati the last three years. He now faces the task of rebuilding a former Southeastern Conference power that has posted three consecutive losing seasons.

Tennessee went after at least two other candidates before hiring Jones.

During the 19-day search to replace Derek Dooley, who was fired Nov. 18 after going 15-21 in his three-year tenure, the Volunteers contacted ESPN analyst and former Super Bowl-winning coach Jon Gruden, who indicated he wasn't interested. The Vols then pursued Charlie Strong, who said Thursday he had turned down their offer and would stay at Louisville.

Jones, meanwhile, was apparently waiting for a job like Tennessee.

On the same day Strong made his announcement, Jones rejected an offer to take over Colorado's program. He also had been linked to the Purdue coaching job before withdrawing his name from consideration.

"I am very pleased that Butch Jones is the head football coach at Tennessee," athletic director Dave Hart said in a school release. "Butch has a track record of success at every program he has led, and he views Tennessee as the job he coveted. We look forward to Butch leading our football program back to prominence."

Jones' hiring means each of the four Southeastern Conference teams that fired coaches this year has filled their vacancies.

Kentucky hired Florida State defensive coordinator Mark Stoops last week to replace Joker Phillips. Arkansas hired Bret Bielema away from Wisconsin on Tuesday to take over for John L. Smith. Auburn selected Arkansas State's Gus Malzahn on Tuesday as the replacement for Gene Chizik.

Jones will be Tennessee's fourth coach in a six-season stretch, not including offensive coordinator Jim Chaney's stint as interim head coach in the 2012 season finale after Dooley's dismissal. Phillip Fulmer was fired after the 2008 season, ending his career with a 152-52 record at Tennessee. Lane Kiffin coached Tennessee in 2009 before leaving for Southern California. Dooley lasted three years.

After winning at least eight games for 16 consecutive seasons from 1989-2004 and posting double-digit wins in nine of those years, Tennessee hasn't earned more than seven victories in any of its last five seasons. The Vols went 5-7 this fall for their fifth losing season over the last eight years. This also is the first time since 1909-11 that Tennessee has finished below .500 three years in a row.

Hart said at the start of the search that head coaching experience was "critically important" and that he wanted a coach who "knows the difficulty of climbing the ladder in the SEC." Jones lacks SEC experience, but he has a career winning percentage of .649. Jones' teams have earned at least a share of a conference title in four of his six seasons as a head coach.

After replacing Notre Dame coach Brian Kelly at Central Michigan and then again at Cincinnati, Jones maintained the momentum his predecessor had established at each school.

In Jones' three-year stint at Central Michigan, the Chippewas won two Mid-American Conference championships and posted a combined league record of 22-3. Jones went 4-8 in his first year at Cincinnati, but the Bearcats are 19-6 since and have tied for first place in the Big East each of the last two seasons. Cincinnati's 2011 season included a 45-23 loss at Tennessee.

Jones signed a contract extension after the 2011 season that includes a $1.4 million buyout if he left before Jan. 1. Cincinnati has made defensive line coach Steve Stripling its interim head coach for the Dec. 27 Belk Bowl against Duke in Charlotte, N.C., while it begins searching for Jones' successor.

"There is no timetable to make the hire," Cincinnati athletic director Whit Babcock said Friday. "Making the right hire is better than the quickest hire, but admittedly sooner is better if possible."

Jones' background as an assistant is entirely on offense, but one of his biggest challenges at Tennessee initially will be strengthening a defense that allowed the most points (35.7) and yards (471.4) per game of any SEC team this season. The Vols hadn't allowed that high a scoring average since 1893, when they gave up 42.7 points per game while playing a six-game schedule. They hadn't yielded that many yards per game since at least 1950, the earliest year Tennessee's sports information department has that statistic on file.

The makeup of Jones' first offense at Tennessee also remains uncertain, at least for now.

Starting quarterback Tyler Bray and star wide receivers Cordarrelle Patterson and Justin Hunter all are projected as first- or second-round draft picks if they choose to turn pro rather than returning to school for their senior seasons. Bray threw for 3,612 yards and 34 touchdowns this year to rank second on Tennessee's single-season list in both categories, behind Peyton Manning's 3,819 yards and 36 touchdown passes in 1997. Hunter caught 73 passes for 1,083 yards and nine touchdowns. Patterson gained a school-record 1,858 all-purpose yards.

Junior offensive tackle Ja'Wuan James also has been mentioned as a possible draft candidate.

___

AP Sports Writers Joe Kay in Cincinnati, Larry Lage in Ann Arbor, Mich., and Teresa Walker in Nashville, contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-12-07-FBC-Tennessee-Jones/id-69fe3f9fc1d145689f75c98b8b8f25d7

c mitt romney mark zuckerberg mark zuckerberg maurice jones drew Yash Chopra George McGovern